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GABA cannot cross the blood-brain-barrier and as such must be synthesized within neurons in the CNS

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The results of a separate mice study investigating how certain proteins 'could underlie some effects of ageing and propensity to age-related diseases' was also published the next day, this time in the Science journal

162 In vitro cell culture and in vivo rat model study showed that melatonin delayed the progression of IL-1-induced IVDD and related LBP via inhibiting the IL-1/NF-B-NLRP3 inflammasome activation positive feedback loop, and downregulating mitochondrial reactive oxygen species (mtROS) production, suggesting melatonin might be a considerable potential clinical agent for IVDD