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doi: 10.1172/JCI122727 64 LiuHJHuHMLiGZZhangYWuFLiuXet al

Abstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS)

Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates

Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

Its often used in detox programs or after prolonged medication use, alcohol exposure, or environmental toxin exposure