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they cross the blood-brain barrier, altering neurotransmitter balance and contributing significantly to the sensation of "brain fog" and central nervous system fatigue

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Post hoc pairwise testing demonstrated a significant difference (without adjustment for multiple testing) at 0, 15, 30 min of the OGTT with an average increase in the p.S539W group of 3.1 pmol/L during this time (Additional file 2: Fig