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There was evidence of a significant reduction in average loop diuretic dose, a lower likelihood of diuretic treatment escalation, and a greater likelihood of diuretic treatment de-escalation with semaglutide versus placebo parameters that indicate disease-modifying effects of semaglutide, and are associated with better long-term clinical outcomes in this patient population. Kavita Sharma, MD, study author Heart failure occurs when the heart is pumping abnormally and it cannot support the circulation demanded by the body