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As is known, ROS plays a major role in atorvastatin induced oxidative stress ( Furthermore, mitochondrial dysfunction, in particular impaired function of the electron transport chain, is frequently associated with in statin-associated skeletal muscle damage ( GPx4 is the most critical ferroptosis defense gene that encodes cytosolic, mitochondrial, and nucleolar isoforms (Figure 10

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Apart from the minor surface alterations seen in 1.5 mM SIN-1-treated group, severe tegumental disruption was observed in schistosomula treated with 3 mM SIN-1

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