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POAG, primary open-angle glaucoma

Both the parent compound and its metabolite are eliminated slowly, with the parent at about 9 days and M1 at about 16 days

Chemosensitivity tests have limitations due to their inability to mimic the exact conditions inside the body of an individual patient

Epigenetic regulation of cell life and death decisions and deregulation in cancer

This has been suggested to promote copper deficiency in AD, as astrocyte ApoE4-mediated copper retention could contribute to reduced neuronal copper availability since astrocytes are key to regulating brain copper levels (Scheiber and Dringen, 2013