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They work synergistically across different metabolic pathways

A crossover study operated on 30 human healthy subjects (380), showed a slight increase in plasmatic GLP-1 and a slight decrease in ghrelin levels 30 min after a Capsaicin enriched meal (containing 1,030 mg of 80,000 Scoville heat units red pepper)

Wahab et al., Journal of Cosmetic Dermatology, 2021 )

10.1016/j.jep.2018.02.043 [DOI] [PubMed] [Google Scholar] 96.Meurer MC, Mees M, Mariano LN, Boeing T, Somensi LB, Mariott M, Dos Santos AC, Longo B, Frana TC, Klein-Jnior LC, de Souza P

Introduction Recently, the intake of fats, sugars, and calories is increasing, whereas exercise and physical activities are reduced