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Among the 37 patients initially put on naltrexone-bupropion, 11 of them (29.7%) continued naltrexone-bupropion up to 18 months, 9 of them (24.3%) continued up to 24 months and 8 of them (21.6%) continued up to 30 months

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An examination of the ratios of plasma to brain total acylcarnitine levels showed a significant decrease in this ratio in E4 mice after challenge with L-carnitine but not in E3 mice, while there was a trend in E2 mice (Figure 9C)

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