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Regeneracin de acil-CoA: La CPT2, en la cara matricial de la membrana interna, libera el grupo acilo del CCAT y lo transfiere a una CoA matricial, produciendo acil-CoA graso dentro de la mitocondria, listo para entrar a la beta-oxidacin
The winning approach isnt picking a drugits designing a system: start with orals where appropriate, reserve high-cost injectables for highest-risk members, and plan for step-up (and step-down) pathways as newer therapies emerge
Comparative data now exist between some of the older AEDs, carbamazepine, phenytoin, and valproic acid and the newer agents, levetiracetam, lamotrigine, and topiramate (low dose) that suggest the older agents increase circulatory vascular risk markers, which may contribute to acceleration of atherosclerosis and that this effect is treatment duration dependent
doi: 10.1016/j.cmet.2019.12.012