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Medication alone is not enough for sustained weight loss or to manage blood glucose levels

Key Takeaways Melanotan-2 activates melanocortin-1 receptors (MC1R) in melanocytes to increase melanin synthesis, with visible pigmentation appearing 4896 hours post-injection due to downstream tyrosinase upregulation and melanosome transfer

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Importantly, mTOR inhibition (e.g., via rapamycin) helps maintain astrocytes in a protective state and reduces neuronal lipid peroxidation damage (Zhang et al., 2025c)