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Diastolic blood pressure also improves, though the effect is somewhat smaller than systolic improvements

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Certain prescription medications like Orlistat or anti-diabetic drugs may assist in fat reduction when combined with a healthy lifestyle, but they should only be taken under medical supervision

Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion from pancreatic -cells in hyperglycemic conditions but is cleaved by dipeptidyl peptidase-4 (DPP-4), an adipokine released in excessive amounts by adipose tissue in patients with obesity [85, 86]

This is a controversial therapy because of these concerns, and research into this potential treatment is ongoing