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Data availability Data will be available in a public repository at Change history 10 July 2025 A Correction to this paper has been published: References Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, et al

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Tirzepatide is well-tolerated in most men, with nausea and constipation being the most common mild side effects that typically resolve within weeks

The peptide reaches peak plasma concentrations within 30 minutes and distributes to various tissues including liver, kidney, gastrointestinal tract, and injured tissues

Stratified analyses revealed low ROR and EBGM05 value for suicide/self-injury in all GLP-1RAs, implying that none of the six GLP-1RA drugs examined in this study were linked to the risk of suicide and/or self-injury in general (Figure 3B,C)