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This activation primarily occurs through the stimulation of the TGF/CTGF pathway, which consequently enriches ECM deposition in aged human skin in vivo

10.1073/pnas.90.17.7915 [DOI] [PMC free article] [PubMed] [Google Scholar] Anderton B., Camarda R., Balakrishnan S., Balakrishnan A., Kohnz R.A., Lim L., Evason K.J., Momcilovic O., Kruttwig K., Huang Q., et al

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