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Ultimately, the early age of onset of diabetes might also be a criterion for the introduction of GLP-1Ra or SGLT-2i, which have been proven to be the only available disease-modifying drugs for T2D

If you suspect an adverse reaction to either medication, report it through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

In addition, proline and GSH related enzymes such as GSH reductase, GSH peroxidases and glutathione S-transferases are also key components of the antioxidant defense system in the cells to scavenge reactive oxygen species (ROS)

Psychological barriers : Some patients experience frustration, get discouraged, or have anxiety related to treatment expectations and results, leading to nonadherence

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