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It is unfortunate that apoptotic involvement of lysosomes, ER, and the cell nucleus in differentiation of erythroid cells is mostly beyond the focus of most studies

In such cases, no treatment is generally required If required, a surgical excision and complete removal of the macule, primarily to address cosmetic issues may be performed Treatment of the underlying associated genetic disorder, if any Follow-up care with regular screening and check-ups are encouraged How can Labial Melanotic Macules be Prevented

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The criteria for defining the degree of follicular invasion to make the diagnosis are still under investigation [45]

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