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Mechanistically, T3 acts to alter the BA composition by targeting CYP8B1, a sterol 12-hydroxylase required for CA synthesis, and then the subsequently altered BA profiles, particularly the increased non-12-OH FXR-antagonistic BAs, potentiates the GLP-1 production and insulin secretion by repressing FXR signaling

Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England

Because they are supplements rather than prescription medications, systemic side effects are less defined, but the lack of clinical testing means overall safety remains uncertain

People with obesity and/or type 2 diabetes

Each of these pharmaceutical classes can enhance glycemic control and carry ancillary benefits, including weight reduction and decreased cardiovascular risk