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Central role of microglia in sepsis-associated encephalopathy: From mechanism to therapy

since this modification blocks formation of the iminium species but not the imoquinone, iminium formation is inferred to be the main cause of toxicity (Kalgutkar et al., 2002)

However, the limited sample size of their study (only 20 patients) may have limited the generalizability of the results, and they failed to investigate the specific receptor-mediated mechanism underlying the effect of SSRIs on tubal motility and the fallopian tubes at different stages of the menstrual cycle

Thus, generalization to all individuals with CUD should be done with caution

The most appropriate option depends on individual needs