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Research protocols use 2 mg daily dosing with studies showing significant effects on visceral adipose tissue reduction and metabolic health improvement

Possible side effects The most common side effects of Wegovy are digestive issues such as nausea, diarrhea, vomiting, constipation, indigestion and heartburn, gas and bloating, as well as headache, fatigue, dizziness, burping, runny nose or sore throat, and low blood pressure

The added GIP and glucagon activity affects metabolic pathways unrelated to thyroid C-cells

Keller S, Reichmann H, Gille G

In comparison, phenformin showed much less impairment of cell growth with a CC 50 of 2060 M in Calu-3 and 1313 M in Huh7.5 cells (Fig