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Some studies suggest that individuals with Hashimoto's disease may develop metabolic complications beyond thyroid dysfunction itself

The average age was 60.7 years, while a large proportion was female (65%)

Front Immunol (2020) 11:610363

Biopsy data shows fibrosis stage progression in a total of 42 patients, either treated or in the placebo arm, no change in 120, and regression in 58

However, aldosterone secretion is regulated by several factors besides ANG II, including potassium concentration, ACTH, and membrane depolarization of zona glomerulosa cells (93)