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Biological function Oxidation mechanism of lipoic acid LA is a natural cofactor with antioxidant capacity, and scavenges reactive oxygen species (ROS) and chelates metal ions [31]

SIRT1 enhances mitochondrial biogenesis and function through deacetylating PGC-1 (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), improving cellular metabolic status (51, 52)