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In laboratory and pre-clinical research settings, glutathione is studied across virtually every area of cellular biology owing to its central, non-redundant role in redox homeostasis and its interactions with dozens of enzyme systems, signalling pathways, and disease-relevant biological processes

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27 Point mutations in the DNA gyrase or topoisomerase IV genes confer fluoroquinolone resistance

In turn, mtDNA damage and mutagenesis are directly responsible for a gradual impairment of the respiratory chain function and thus increase electron leakage and ROS production in the mitochondria