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& Locksley, R

[ Google scholar ] Pickart L, Vasquez-Soltero JM, Margolina A

Structural modifications allow them to stay in circulation for hours or even days: IGF-1 LR3 : 2030 hour half-life CJC-1295 with DAC : 58 day half-life PEG-MGF : detectable for up to 12 weeks Pharmacokinetic enhancements such as PEGylation or fatty acid acylation extend the peptides residence time, reduce renal clearance, and improve therapeutic utility. Veronese & Mero, BioDrugs What Determines How Long Peptides Stay in Your System

The main theoretical concern is angiogenesis BPC-157 promotes new blood vessel formation, which is great for healing but theoretically undesirable if you have a condition where blood vessel growth is problematic (active cancer is the primary example)

73 In this context, differentiation between chronological and biological age is necessary