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DEP domain containing 5 (DEPDC5) deficient CD8 + T cells exhibit spontaneous ferroptosis due to mTORC1-induced Activating Transcription Factor 4(ATF4) upregulation, leading to elevated xanthine oxidase activity and lipid ROS accumulation [92]

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Adrian clarifies that while it can be a potent ally in survivorship and secondary prevention, its use during conventional cancer treatments like chemotherapy and radiotherapy is discouraged due to potential interference with these therapies