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SGLT-2 is expressed in the proximal tubule and mediates re-absorption of ~90% of filtered glucose Rx of Heart Failure : There is accumulating evidence for numerous additional mechanisms of action separate from SGLT2 inhibition that may underlie the ability of gliflozins to produce favorable outcomes in the treatment of heart failure

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[DOI] [PubMed] [Google Scholar] 15.Miladinovi ., Muheim C., Bauer S., Spinnler A., Noain D., Bandarabadi M., Gallusser B., Krummenacher G., Baumann C., Adamantidis A

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