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The first converts homocysteine to methionine, which supports DNA synthesis and red cell production

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

This guide helps clinicians make well-informed recommendations based on individual patient needs

Careful explanation was sufficient reassurance that there would be no untoward effects

B12 ensures that the body produces an adequate supply of red blood cells, which are responsible for delivering oxygen to tissues and organs