Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism
However, like all medications, they may be associated with certain side effects, such as gastrointestinal issues, including nausea, vomiting, diarrhea, and constipation
Athletes aiming for lean muscle may choose L-Carnitine, while those needing cognitive enhancement often go for ALCAR
Study have shown berberine can inhibit A-induced microglial activation mediated by suppressor of cytokine signaling 1 (SOCS1) (Liang et al., 2021)
Conflicts of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
