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Traditional agents such as vitamin D analogues and retinoids primarily act by normalizing keratinocyte proliferation and differentiation

GLP-1 Receptors and Skin Inflammation Beyond the indirect effects of weight loss, GLP-1 receptors are present in skin tissue, including in keratinocytes, the primary cells of the outer skin layer, and in immune cells resident in skin

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These changes happen gradually over weeks, which is why starting low and adjusting upward produces better long-term adherence than aggressive dosing