Injecting too deeply (into muscle) can cause pain, bruising, and altered absorption, whilst too shallow an injection may cause medication leakage or skin irritation
Data from similar medications shows significant weight regain within 12-18 months of discontinuation
The other factor is that patents for GLP-1s are set to expire in large markets like China, India, Brazil, Canada and Turkey, where 40% of the global population (and roughly 33% of adults considered obese) live
Anal Biochem 241:140142 Zalazar L, Saez Lancellotti TE, Clementi M, Lombardo C, Lamattina L, De Castro R, Forns MW, Cesari A (2012) SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity
(Dec 2023) Qsymia and Cost: What You Need to Know