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In the meta-analysis, SGLT2 inhibitors significantly reduced major adverse cardiovascular events (MACE), hospitalization for heart failure (HF) plus CV death, and progression of CKD by 11%, 23% and 33%, respectively, compared to placebo

In animal studies, it has been linked to a slightly increased risk of birth defects and low birth weight

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Sustained treatment with tesofensine has been shown to improve overall mood through its antidepressant effect