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These shortages have since abated, though, and the FDA has tried to crack down on the practice in recent years

Berberine, a bioactive alkaloid derived from various plants, including Berberis species, has garnered significant attention as a nutraceutical agent due to its potential benefits in metabolic health

Concurrent Use of Alcohol and Other Central Nervous System Depressants Patients should be advised to avoid concurrent use of RYALTRIS with alcohol or other CNS depressants because additional reductions in alertness and additional impairment of CNS performance may occur [see Warnings and Precautions (5.2)]