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Walking 10,000 steps daily matters less if you've unconsciously reduced your baseline movement by 3,000 steps

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial

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The management challenge is getting through the early phase with minimal discomfort while the weight loss catches up to provide its own protective effect