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Table I [i] PIO pioglitazone, GLP-1R glucagon-like peptide 1 receptor, SGLT2 sodium-glucose co-transporters 2, TOFO tofogliflozin, SUL sulfonylurea, MET metformin, DAPA dapagliflozin, EXE exenatide, NAFLD non-alcoholic fatty liver disease, T2D type 2 diabetes, A1C glycated hemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase, -GT gamma-glutamyl transferase, MRI-PDFF MRI-proton density fat fraction, MRE-LSM MR elastography-liver stiffness, RCT randomized controlled trial, EDICT Efficacy and Durability of Initial Combination Therapy, CAP controlled attenuation parameter, LSM liver stiffness measurement, BMI body mass index
38 Liraglutide Liraglutide is a 31 aa-long synthetic peptide drug attached to 16 carbon fatty acids (MW: 3751 g/mol) (Figure 1D)
Common medications include semaglutide and tirzepatide
When semaglutide activates these pathways, some patients experience heightened sensitivity to dehydration, signaling your brain that fluid intake is needed even if your body's actual hydration status is adequate
it manipulates neutrophil activation indirectly by engaging the dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN, CD209) receptor on dendritic cells via its envelope glycoprotein gp120 [116, 117]
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