Hawkins CL, Morgan PE, Davies MJ (2009) Quantification of protein modification by oxidants
Conversely, glutathione deficiency plays a major role in the development of depression, anxiety, and related conditions: Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ) Diminished GSH levels elevate cellular vulnerability towards oxidative stress . The bottom line : eliminating oxidative stress in the brain by way of glutathione is proven to enhance cognition and fight depression
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(ii) severe systemic inflammation (cytokine storm), with damage to the blood-brain barrier and immune infiltration
Chronic hypoxia, such as environmental hypoxia and tissue hypoxia, is common [3, 4]