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Lower baseline VAT metabolism levels were associated with greater weight reduction by GLP-1 medications, thus indicating that people with low VAT metabolic activities might benefit the most from the dual effects of GLP-1 treatment on reduced calorie intake and enhanced metabolic activity

This physicochemical advantage broadens its practical applicability, offering a more convenient and versatile route of administration for various therapeutic targets, which is a significant benefit for potential clinical use and patient compliance

Since excess weight worsens insulin resistance, the weight loss produced by GLP-1 medications actually improves the underlying metabolic dysfunction