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46 More broadly, the shortages led to documented cases of rationing, delayed surgeries, and substitution with less effective products

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However, we did observe that ML226 drove a memory T cell phenotype, as after 11 days of treatment, there was an increase in the CCR7 high CD45RO high central memory T cell population (T CM ), and a corresponding decrease in the CCR7 low CD45RO high effector memory T cell population (T EM