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Proc Natl Acad Sci USA (2019) 116(13):637984

Unlike other antioxidants that work in specific tissues or target particular free radicals, glutathione functions as a comprehensive cellular protection system

Use and conservation of medicinal plants by indigenous people of Gozamin Wereda, east Gojjam zone of Amhara region, Ethiopia: an ethnobotanical approach

For example, glucose-stimulated insulin release is principally regulated by SSTR5 in rodent cells whereas the SST effects are predominantly mediated by SSTR2 in human cells 43,44

Similarly, in vitro studies on Schisandra lignans have demonstrated that they activate the Nrf2-ARE pathway, increasing the activity of Phase II enzymes like NQO1 by over 4.3-fold, providing profound hepatoprotection against chemical toxicity