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Pain Animal studies have shown beneficial effects of B12 on the regeneration of nerves and the inhibition of pain-signalling pathways, including cyclooxygenase enzymes

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Phase II human trials of thymosin beta-4 (TB-500's parent molecule) have been conducted examining tissue repair rates, with studies reporting acceleration of repair in patients with pressure ulcers, stasis ulcers, and epidermolysis bullosa wounds, though detailed results remain limited in peer-reviewed literature

For those following a vegetarian or vegan diet, B12 is naturally scarce