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This effect may be attributed to an increase in the number of glutamatergic neurons within the BLA, which subsequently led to a reduction in the projection of the neural repair protein GLP-1 in the NTS-BLA pathway [46], and a downregulation of c-Fos expression in the BLA
This clinical trial showed that Tirzepatide resulted in a weight reduction of 15-20% of starting body weight for those taking Tirzepatide at 72 weeks, while those in the placebo group saw an average weight reduction of 3%
Hypertension 34 , 151159 (1999)
Brain Res 1717:235246 Srivastava S, Singh D, Patel S, Singh MR (2017) Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders
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