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PMCID: PMC5098151.

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(2019) demonstrated that the water content of spinal cord tissue decreased significantly after melatonin administration and that melatonin downregulated the expression of the aquaporin aquaporin-4 ( Melatonin prevents the down-regulation of neuroplasticity after spinal cord injury Melatonin treatment after SCI significantly increased the mRNA and protein expression levels of growth associated protein-43 (GAP-43), synapsin1, Neurofilament 200 (NF200) and Postsynaptic density protein 95 (PSD-95) ( Conclusion The complications after SCI greatly impact quality of life and life expectancy, especially constipation and fecal incontinence caused by gastrointestinal and bladder dysfunction (Zhang et al., 2018)

Applicable Procedure Codes: J1950, J1951, J1952, J1954, J3315, J3316, J9155, J9202, J9217, J9226