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The next step was testing for PABA in the plasma or urine, which could distinguish between control animals and those suffering from exocrine pancreatic insufficiency (EPI) without affecting the outcome when the xylose absorption test was combined with pancreatic function

However, this particular dose is indicated for sleep-related pathologies such as jet-lag and works by targeting the central nervous system where canonical melatonin receptors are abundantly expressed (69)

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Vitamin D upregulates RFC at the blood-brain barrierthe pathway that Leucovorin uses to enter the brain

10.1016/j.clnu.2022.10.024 52 HornD.BarrientosA