doi:10.1111/j.1365-2125.2007.02890.x
Here we will consider only hyperpigmentation treatment by the orobuccal route
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Guidelines continue to be revised however, and basal insulin therapy is now often used much sooner and frequently in combination with oral agents or glucagon-like peptide-1 receptor agonists (GLP-1 RAs), rather than postponing insulin therapy until lifestyle modifications and oral agent treatment has failed [2, 3]
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