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Those hormones signal your brain to reduce hunger and slow how fast your stomach empties

Cannabis may counteract Ozempic's appetite-suppressing effects through THC-induced hunger, potentially undermining weight management and glycaemic control

Semaglutide is a synthetic version of a naturally occurring hormone that helps control blood sugar levels and reduce appetite

The changes are most prominent in cecum and rectum , although it can affect the entire large bowel

Mounjaro (Tirzepatide) , held by Eli-Lilly, initially registered for Type 2 Diabetes in December 2024, was granted approval for medical weight loss by SAHPRA in October 2025