Multiple rodent models of PCOS, capitalizing mainly on the impact of androgen excess at different developmental windows, with variable penetrance in terms of reproductive and metabolic impairment, have been used in translational studies, in order to capture the phenotypic heterogeneity of the syndrome 38
The switch process is straightforward

You should discuss cancer concerns with your GP or specialist before starting a GLP-1 medicine if you have: Personal history of any cancer, particularly thyroid or pancreatic malignancies Family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Previous episodes of pancreatitis Unexplained symptoms such as persistent abdominal pain, neck lumps, or difficulty swallowing Anxiety about cancer risk that may affect medicine adherence During treatment with a GLP-1 medicine, contact your healthcare provider promptly if you develop: A lump or swelling in the neck Persistent hoarseness or voice changes Difficulty swallowing or breathing Severe, persistent abdominal pain, especially if radiating to the back (seek urgent medical help via NHS 111 or A&E if severe) Unexpected or disproportionate weight loss relative to your dose and treatment plan, especially with other concerning symptoms Any other worrying symptoms It is important to maintain perspective: the proven cardiovascular benefits of GLP-1 medicines in reducing heart attack, stroke, and cardiovascular death substantially outweigh theoretical cancer concerns for most patients

Development and role of HO-1 in regulating diabetic nephropathy Diabetic nephropathy (DN) is a widespread factor contributing to the morbidity and mortality in patients with T1DM and T2DM
Diabetes Care 32 , S62S67 (2009)