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The most common adverse effects documented in tirzepatide clinical trials are gastrointestinal in nature, including nausea, diarrhea, vomiting, constipation, and abdominal discomfort

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Metformin, known primarily for stimulating autophagy and apoptosis via the EGFR/AKT/AMPK/mTOR pathway in SCLC (92), may indirectly influence ferroptosis given the central role of the AMPK/mTOR hub in this crosstalk, although direct evidence is required

Innate Immune Cells Myeloid Cells: Dendritic Cells and Macrophages Activation of DC through Toll-like receptors (TLRs) is a crucial step for DC activation, maturation, as well as antigen processing and presentation

Pain 15 , 153160 (2011)