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What the Evidence Shows on Compounded Bioidentical HRT The Menopause Society (formerly NAMS) published a 2020 position statement noting: "Compounded bioidentical hormone therapy (cBHT) is not recommended over FDA-approved bioidentical hormone therapy due to concerns about safety, quality, and the lack of clinical trial data." [11] That position reflects the absence of randomized controlled trials powered to show efficacy or long-term safety for compounded formulations specifically, not for the hormones themselves

100300 mcg once daily with gradual titration

10.3390/ijms21103415 109 PinartM.KellerT.ReichA.FrhlichM.CabiesesB.HohmannC.et al (2017)

Different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated tau: implications for amyloid- and tau pathology in Alzheimers disease

A good starting point is the same per-weight guidance above