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Then researchers move to humans so they are confident that it could work and when they are willing to invest in much more expensive research

Exenatide (Ex), a 39-amino-acid GLP-1 analogue peptide, is a potent agonist with high affinity for GLP-1Rs and has a significantly longer biological half-life than the exogenously administered GLP-1, which makes it an efficient treatment option in noninsulin-dependent diabetes mellitus [14,15,16,17]

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