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CagriSema uses both pathways together, which is why it outperforms either drug taken alone

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Tryptase, prostaglandins, leukotrienes, and various cytokines continue to cause inflammation, tissue damage, and immune activation even when histamine receptors are blocked

Unlike the spray pattern (which does not require PBE analysis), plume geometry equivalence is assessed with the criterion that the test products plume angle and width fall within 90111% of the reference product values