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[1] It's important to note that GLP-1 receptor agonists are not indicated for heart failure treatment, and SGLT2 inhibitors are the preferred agents with established benefits in heart failure according to current guidelines

206,210 Additionally, activation of GLP-1R has been demonstrated to promote cell survival during glucotoxic and lipotoxic conditions, excessive nitric oxide levels, Ca 2+ depletion, oxidative stress, and cytokine-induced endoplasmic reticulum stress in primary beta-cells and cell lines

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