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Budesonide with EEL modulates the expression of -SMA and Ki-67, markers of airway smooth muscle cell proliferation, and comprehensively affects the TGF/Smads pathway by decreasing TGF1 and Smad3 while increasing Smad7, more effectively than either component alone [249]

Kaur, Tejinder1

Starting with the lowest effective doses of both compounds and gradually titrating upward allows for better symptom monitoring and safety assessment

doi:10.1016/j.exger.2020.110949 Akirov A, Greenman Y, Glaser B, et al

Full specifications and reference information are maintained in the official Pfizer labeling document: Pfizer Labeling (Official Document)