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Two studies (33, 34) reported effects of urolithin A on the central clock

While they share a common mechanismmimicking the GLP-1 hormone to stimulate insulin secretion, suppress glucagon release, and slow gastric emptyingthey differ in their molecular structures, dosing schedules, efficacy, and side effect profiles

Medullary Thyroid Carcinoma History Personal or family history of MTC or MEN2 syndrome is a contraindication for all GLP-1 agonists History of Pancreatitis GLP-1 medications may increase pancreatitis risk

doi: 10.1016/j.envres.2020.109202 82 WamelinkG

All GLP-1RAs have been found to cross the bloodbrain barrier (BBB) and stimulate GLP-1 receptors in the brain, thus offering neuroprotection [17]